Reduced Distance Matrix to Verify the Similarity between Protein Structures

Abstract This paper focuses on developing a reduced distance matrix to improve the computational performance during the protein interactions clustering. This proposed matrix considers as centroids two alpha carbon atoms from a protein structure and stores the distances between these centroids and the other atoms from this same structure. Each row in this matrix represents a database record and each column is a distance value. Through this build matrix, clusters were performed using K-Means Clustering. The precision and performance of this presented technique were compared with aCSM, RID and another distance matrix methodology that considers the distances between all atoms from each protein structure. The results were satisfactory. The reduced distance matrix obtained a high precision and the best computational performance.

Prediction of Drug–Drug Interactions by Using Profile Fingerprint Vectors and Protein Similarities / 대한의료정보학회지

A neurociência computacional no estudo dos processos cognitivos / Neuroscience computationnelle dans l'étude des processus cognitifs / La neurociencia computacional en el estudio de los procesos cognitivos / Computational neuroscience in the study of cognitive processes

Resumo Nas últimas décadas o estudo de processos cognitivos vem sendo influenciado por duas tendências: a legitimação de diversas formas e níveis de estudo e a tentativa de integração multidisciplinar. A primeira teve grande importância na segunda metade do século XX, quando linhas de pesquisa na psicologia cognitiva e nas neurociências fortaleceram-se. Nesse sentido, destacam-se os três níveis de Marr (computacional, algorítmico e implementacional) como forma de estruturar o estudo dos processos cognitivos. A segunda tendência é mais recente e busca, apoiada na primeira, aprofundar o entendimento dos processos cognitivos em suas diversas escalas e integrar diversos paradigmas de estudos, buscando consiliência teórica. O intento deste artigo é apresentar a neurociência computacional e suas possíveis contribuições para a psicologia cognitiva, articulando, por meio dos três níveis de Marr, uma base teórica que explicite o papel de cada uma das disciplinas e as suas possíveis interações.

Résumé Au long des dernières décennies, l'étude des processus cognitifs se voit influencé par deux tendances : la légitimation de plusieurs formes et niveaux d'études et l'essai d'intégration multidisciplinaire. La première a eu une grande importance pendant la deuxième moitié du XXe siècle, quand des lignes de recherche en psychologie cognitive et en neurosciences ont gagné force. Dans ce sens, on peut souligner les trois niveaux de Marr (computationnel, algorithmique et implémentationnel) comme moyens de structurer l'étude des procédés cognitifs. La deuxième tendance est plus récente et cherche, avec l'aide de la première, à approfondir la connaissance des procédés cognitifs et ses différentes échelles et à intégrer plusieurs modèles d'études, en cherchant des convergences théoriques. Le but de cet article est donc de présenter la neuroscience computationnelle et ses possibles contributions pour la psychologie cognitive en articulant, par les trois niveaux de Marr, une base théorique qui puisse expliciter le rôle de chacune des disciplines et de ses possibles interactions.

Resumen En las últimas décadas, el estudio de procesos cognitivos se ha visto influenciado por dos tendencias: la legitimación de diversas formas y niveles de estudio, y el intento de integración multidisciplinar. La primera tuvo gran importancia en la segunda mitad del siglo XX, cuando varias líneas de investigación en la psicología cognitiva y en las neurociencias se fortalecieron. En ese sentido, destacan los tres niveles de Marr (computacional, algorítmico e implementacional) como una manera de estructurar el estudio de los procesos cognitivos. La segunda tendencia es más reciente y busca, apoyada en la primera, profundizar la comprensión de los procesos cognitivos en sus diversas escalas e integrar diversos paradigmas de estudios, buscando consiliencia teórica. En este artículo, se intenta presentar la neurociencia computacional y sus posibles contribuciones para la psicología cognitiva, articulando, a través de los tres niveles de Marr, una base teórica que ponga de manifiesto el papel de cada una de las disciplinas y sus posibles interacciones.

Abstract In recent decades the study of cognitive processes has been influenced by two tendencies: legitimation of several forms and levels of study and the attempt of multidisciplinary integration. The first had great importance in the second half of the 20th century, when research lines in cognitive psychology and neuroscience were strengthened. In this sense, Marr's three levels of analysis (computational, algorithmic, and implementation) are one way to structure the study of cognitive processes. The second tendency is more recent and, supported by the first one, seeks to deepen the understanding of cognitive processes in their different scales and to integrate several paradigms of studies in order to reach theoretical consilience. This article aims to introduce computational neuroscience and its possible contributions to cognitive psychology, articulating, through Marr's three levels, a theoretical basis that explains the role of each of the disciplines and their possible interactions.

La ola de los meta-análisis en red: una herramienta cada vez más útil para la toma de decisiones / The wave of network meta-analysis: an increasingly useful tool for decision making

Cuando no disponemos de estudios que cotejen directamente las ventajas y desventajas de dos intervenciones, o cuando se necesita un ranking de las mejores intervenciones, este nuevo tipo de estudio ofrece una respuesta. En este artículo, el autor explica en qué consiste el meta-análisis en red y los requisitos que deben cumplir los estudios primarios para que sus resultados puedan ser combinados con esta metodología. (AU)

When studies comparing risks and benefits of two interventions are not available, or when a ranking of the best interventions is needed, this new type of study offers an answer to clinical questions. In this article, the author explains what network meta-analysis is and what requirements primary studies must fulfill so that their results can be combined with this methodology. (AU)

Computational drug discovery for the Zika virus

Few Zika virus (ZIKV) outbreaks had been reported since its first detection in 1947, until the recent epidemics occurred in South America (2014/2015) and expeditiously became a global public health emergency. This arbovirus reached 0.5-1.3 million cases of ZIKV infection in Brazil in 2015 and rapidly spread in new geographic areas such as the Americas. Despite the mild symptoms of the Zika fever, the major concern is related to the related severe neurological disorders, especially microcephaly in newborns. Advances in ZIKV drug discovery have been made recently and constitute promising approaches to ZIKV treatment. In this review, we summarize current computational drug discovery efforts and their applicability to discovery of anti-ZIKV drugs. Lastly, we present successful examples of the use of computational approaches to ZIKV drug discovery.

Comparing open wound measuring methods popularly used in experimental studies / Estudo comparativo de métodos de avaliação de contração de feridas cutâneas abertas

Tissue repair is a response reaction to lesions and aggressions that constitutes a dynamic process to maintain the integrity of the organism. Wound healing experiments have used several approaches in order to assess and compare treatment methods, and these discrepancies hamper comparisons among assays. This study assessed three different methods of wound measurement commonly used in healing assays: clock method, graph paper method, and computer-assisted image analysis. We used 30 Wistar rats, kept in appropriate conditions for animal well-being. After anesthesia, and using an eight-millimeter punch, two lesions were made in the back region of each rat. The wounds were assessed on days four, seven, and 14 after infliction. At four days, all methods generated similar results. By day seven, the clock method had lost precision, likely due to wound shrinkage, and yielded greater means compared to the other two methods. On the last assessment, the computer-assisted method appeared to have more precise results, with the other two generating statistically higher means. Computer-assisted image analysis seems to have maintained wound measuring precision throughout this experiment, even when faced with small lesions. Considering these results, the authors recommend the use of computer-assisted measurements in future experiments.

O reparo tecidual surge em resposta às lesões e constitui-se de um processo dinâmico para manutenção da integridade do organismo. Nos estudos sobre cicatrização de feridas, tem se utilizado várias técnicas buscando-se uma avaliação da eficácia de meios de tratamento local. Sendo assim, o presente trabalho objetivou comparar três métodos de avaliação experimental de áreas de feridas, sendo eles: o método do relógio, papel milimetrado e avaliação computadorizada. Para realização do experimento, foram utilizados 30 ratos Wistar em condições de bem-estar. Após realizada a anestesia, foram confeccionadas duas lesões no dorso de cada animal com punch de 8 mm, sendo as feridas avaliadas após quatro, sete e 14 dias de tratamento. Observou-se que aos quatro dias de tratamento, todos os métodos apresentaram o mesmo desempenho, enquanto aos sete e 14 dias, o método do relógio, apresentou maior média de área, perdendo precisão, e aos 14 dias, a avaliação computadorizada apresentou resultados mais precisos em relação a ambos os outros métodos. Concluiu-se que a avaliação computadorizada através de software de áreas de feridas cutâneas apresenta resultados mais precisos em relação aos métodos do relógio e papel milimetrado, principalmente em lesões menores.

Aplicación de los modelos mecanobiológicos en los procesos de regeneración ósea / Application of mechano-biological models in bone regeneration process / Mise en application des modèles biomécaniques dans les processus de régénération osseuse

Los modelos computacionales constituyen una herramienta necesaria en las investigaciones científicas. En este trabajo se muestra la utilización de las nuevas tecnologías, a través del Método de los Elementos Finitos en la implementación de los modelos mecanobiológicos usados en ortopedia. Se exponen los principales modelos mecano-reguladores que aparecen en la bibliografía y se ejemplifican las ventajas que proporcionan las técnicas de modelación en el pronóstico de la formación de nuevo tejido óseo, como respuesta biológica del organismo debido a la aplicación de cargas externas.

Computational models are a necessary tool in scientific researches. This paper deals with the use of new technologies, by using the Finite Element Method for the implementation of mechano-biological models used in orthopedic. Also the main mechano-regulator models are shown in this article, which are described in literature. On the other hand, the advantages provided by the modeling techniques during the prognosis of the new tissue formation, as a response of the organism to the application of external loads are stated by these authors.

Les modèles informatisées constituent un outil nécessaire dans les recherches scientifiques. Dans ce travail, on montre l’usage des nouvelles technologies, telle que la méthode des Éléments finis, dans la mise en application des modèles biomécaniques utilisés en orthopédie. On fait une révision des modèles mécano-régulateurs principaux apparus dans la littérature, et on met des exemples des bénéfices obtenus par les techniques de modélisation dans le pronostic de formation du nouveau tissu osseux comme réponse biologique du corps aux charges externes.

Modelagem molecular aplicada à elucidação dos mecanismos envolvidos na ação antiproliferativa e hemolítica das alquilfosfocolinas / Molecular modeling applied to the elucidation of the antiproliferative and hemolytic mechanisms of action of alkylphosphocholines

As alquilfosfocolinas (APC) são uma classe de fármacos derivados de fosfolipídios endógenos que apresentam potencial antitumoral. Diferentemente de outros fármacos antitumorais que agem no DNA da célula, as APCs têm como primeiro local de ação a membrana plasmática e proteínas de sinalização, como a PKC. O objetivo desse trabalho é elucidar, através de metodologias computacionais, os possíveis mecanismos de ação das APCs que provocam hemólise, inibição da PKC e interação com membranas celulares. Inicialmente, a toxicidade de um conjunto de 34 APCs foi estudada pelos métodos quimiométricos de Análise de Agrupamentos Hierárquicos (HCA) e Componentes Principais (PCA). As moléculas foram simuladas com dinâmica molecular (DM) e propriedades físico-químicas e estruturais foram calculadas para os confôrmeros de menor energia. Após aplicação de HCA e PCA, as APCs foram divididas em 3 grupos, de acordo com suas características estruturais. Os resultados sugerem que a presença de grupos catiônicos volumosos, ou anéis como adamantila e ciclohexila, aumentam a hemólise de compostos de cadeia alquílica longa. Anéis macrocíclicos como ciclopentadecila parecem ser importantes para o potencial hemolítico de compostos com cadeia alquílica curta. Com relação a compostos sem anéis e de cadeia linear, grupos catiônicos menos volumosos parecem favorecer a hemólise. Na próxima etapa do estudo, 7 derivados de APC, com diferentes grupos catiônicos, foram selecionados e ancorados no domínio C2 da PKCα. O intuito foi mapear resíduos de aminoácidos importantes para a interação dos ligantes com a enzima, e comparar com o modo de ligação do ativador endógeno fosfatidilserina (PS). Mais uma vez, HCA e PCA foram aplicados para extrair informação relevante do mapeamento. Os resultados mostraram que as cadeias laterais de Pro188, Asn189, Arg216, Trp247, Asp249 e Thr250 não permitem a aproximação adequada do ligante, o que impede que a porção fosforila se coordene com um dos átomos de cálcio. A porção catiônica da PS, em contrapartida, consegue estabelecer ligação-hidrogênio com Asn189 de forma a posicionar os oxigênios da fosforila para interagir, ao mesmo tempo, com o átomo de cálcio. Com menos pontos de coordenação, a afinidade de ligação do cálcio pela PKCα diminui e a ativação da enzima fica comprometida, interrompendo toda a cascata de sinalização que depende dela. A parte final desse trabalho se dedicou ao estudo da interação da miltefosina com diferentes bicamadas lipídicas sob o ponto de vista termodinâmico. Oito bicamadas de diferentes fosfolipídios foram simuladas por DM e a interação energética da miltefosina foi calculada por Umbrella Sampling. Os resultados mostraram que a miltefosina apresenta maior partição em bicamadas contendo colesterol, sendo a miscibilidade nesses sistemas cerca de 76 vezes maior que os valores encontrados para bicamadas sem colesterol. Além disso, verificou-se que a internalização da miltefosina é mais fácil em regiões contendo lipídeos poli-insaturados, provavelmente devido ao empacotamento mais frouxo da bicamada. Os dados sugerem que a miltefosina age principalmente em rafts lipídicos e que células contendo mais lipídicos poli-insaturados podem incorporar maior quantidade do fármaco

Alquilfosfocolines (APCs) comprise a class of drugs with antitumor activity derived from endogenous phospholipids. Differently from other drugs whose primary site of action is the DNA, APCs act firstly in the plasma membrane and signaling proteins, such as PKC. The main objective of this work is to elucidate, via computational approaches, the possible mechanisms of actions that cause hemolysis, PKC inhibition and interaction with cellular membranes. Initially, a set of 34 APCs was studied by means of Hierarchical Cluster Analysis (HCA) and Principal Component Analysis (PCA). The molecules were simulated by means of molecular dynamics simulations (MD) and molecular and structural properties were calculated for the lowest-energy conformer. After HCA and PCA methodologies, the set was divided into 3 groups according to their structural features. The findings suggest that the presence of bulky cationic moieties, or the adamantyl and cyclohexil rings, increase the hemolytic potential of compounds with long alkyl chains. Macrocyclic rings, such as cyclopentadecyl, seem to be important to elevate the hemolysis of compounds with short alkyl chains. Regarding linear carbon chain derivatives with no ring substitution, less bulky cationic head groups seem to favor hemolysis. In the next step of this work, 7 APC derivatives were selected and docked in the C2 domain of PKCα. The aim now was to map the residues relevant for ligands interaction compared to the binding mode of the endogenous activator, phosphatidylserine (PS). HCA and PCA were again applied in order to extract relevant information from the mapping. The results showed that the lateral chains of Pro188, Asn189, Arg216, Trp247, Asp249 and Thr250 do not allow the proper approximation of the ligands, impeding the phosphoryl moiety from coordinating with one of the calcium atoms. On the other hand, the cationic moiety of PS forms hydrogen-bonding with Asn189 in order to position the oxygens to interact, at the same time, with a calcium atom. With less coordination sites, calcium binding affinity diminishes and the enzyme activation is compromised, interrupting the signaling cascade. The final part of this work was dedicated to the study of miltefosine interaction with different lipid bilayers from the thermodynamics standpoint. Eight bilayers were simulated with MD and the energetic interaction was calculated via Umbrella Sampling simulations. The findings showed that miltefosine has higher partition in bilayers containing cholesterol, with miscibility of about 76 times higher than the values referring to bilayers without cholesterol. Moreover, it was observed that the internalization of miltefosine is facilitated in regions containing polyunsaturated lipids, probably due to the looser packing. The data suggest that miltefosine acts primarily in lipid rafts, and that cells containing more polyunsaturated lipids in their membranes can incorporate higher quantities of this drug

The prospect of using bioinformatics technology in the field of biological medicine in the era of big data / 药学学报

With the advanced development of information technology, there is a huge impact on various industries for the arrival of big data. In the biomedical field, innovative genome sequencing technology enables low-cost, high-throughput, and high-speed to become a reality, which leads to an explosive growth in data and also appeared in an urgent need to process those massive biological information. High performance computing (HPC) along with effective methods is one of the best ways to deal with the problem of big data in biomedical field which could serve the biomedical development best. We discussed the issues faced in biomedical big data processing and concluded that the bioinformatics is an indispensable component of biomedical technologies.

Research on the performance comparing and building of affective computing database based on physiological parameters / 生物医学工程学杂志

The validity and reasonableness of emotional data are the key issues in the cognitive affective computing research. Effects of the emotion recognition are decided by the quality of selected data directly. Therefore, it is an important part of affective computing research to build affective computing database with good performance, so that it is the hot spot of research in this field. In this paper, the performance of two classical cognitive affective computing databases, the Massachusetts Institute of Technology (MIT) cognitive affective computing database and Germany Augsburg University emotion recognition database were compared, their data structure and data types were compared respectively, and emotional recognition effect based on the data were studied comparatively. The results indicated that the analysis based on the physical parameters could get the effective emotional recognition, and would be a feasible method of pressure emotional evaluation. Because of the lack of stress emotional evaluation data based on the physiological parameters domestically, there is not a public stress emotional database. We hereby built a dataset for the stress evaluation towards the high stress group in colleges, candidates of postgraduates of Ph. D and master as the subjects. We then acquired their physiological parameters, and performed the pressure analysis based on this database. The results indicated that this dataset had a certain reference value for the stress evaluation, and we hope this research can provide a reference and support for emotion evaluation and analysis.

Weighted TOPSIS method and weighted RSR method in the construction of drug supervision and supply networks in rural areas of Hunan / 中南大学学报(医学版)

OBJECTIVE@#To evaluate the rationality and validity of weighted TOPSIS method and weighted RSR method to evaluate drug supervision and supply networks construction in rural areas of Hunan .@*METHODS@#Data of drug network construction in rural Hunan in 2010 were used to establish a comprehensive evaluation model, and weighted TOPSIS and RSR method were applied to this model and the results of which were compared to that of synthetical scored method to examine the validity.@*RESULTS@#A comprehensive evaluation model was established, comprising of 3 primary indices, 8 secondary indices and 56 tertiary ones. The result of weighted RSR method was highly correlated to that of synthetical scored method, yet the result of TOPSIS was less correlated to the formers. All correlations were significant (P<0.01).@*CONCLUSION@#Both weighted RSR and TOPSIS are not perfect methods, but the application of the methods in drug network evaluation is scientific and effective.

Mobile phone based data acquisition and evaluation system for the alternative four diagnostic methods of traditional Chinese medicine / 中国医疗器械杂志

This study is dedicated to integrate the theories of the four diagnostic methods of TCM and the methods of mobile healthcare so as to achieve the goal of the four diagnostic functions of TCM on mobile phone. An Android smartphone based data acquisition system has been developed and experimentally demonstrated. It was shown that the prototype could successfully achieve the fundamental function of the four diagnostic methods of TCM and thus help preliminarily interpret the symptoms of human diseases.

Distribuição de estresse em incisivo central superior sob situações traumáticas semelhantes com diferentes cargas: uma análise tridimensional de elementos finitos / Stress distribuition on maxillary central incisor under similar traumatic situations with different loading forces: a 3-D finite element analysis

Aim: The present study aimed to analyze the stress distribution in the dentoalveolar structures of a maxillary central incisor submitted to two situations of impact loading. Materials and Methods: The following loading forces were applied using a three-dimensional finite element model: a force of 500 N at an angle of 45° on the buccal surface of the crown and a 2000 N force acting in the same direction and surface of the tooth. Results: Harmful stress was observed in the second situation, suggesting damage to both the tooth and adjacent tissue. However, the damage found in soft tissues such as dental pulp, was negligible. Conclusion: Injuries resulting from the traumatic situations were more damaging to the integrity of the tooth and its associated hard-tissue structures.

Archetype Model-Driven Development Framework for EHR Web System / 대한의료정보학회지

OBJECTIVES: This article describes the Web application framework for Electronic Health Records (EHRs) we have developed to reduce construction costs for EHR sytems. METHODS: The openEHR project has developed clinical model driven architecture for future-proof interoperable EHR systems. This project provides the specifications to standardize clinical domain model implementations, upon which the ISO/CEN 13606 standards are based. The reference implementation has been formally described in Eiffel. Moreover C# and Java implementations have been developed as reference. While scripting languages had been more popular because of their higher efficiency and faster development in recent years, they had not been involved in the openEHR implementations. From 2007, we have used the Ruby language and Ruby on Rails (RoR) as an agile development platform to implement EHR systems, which is in conformity with the openEHR specifications. RESULTS: We implemented almost all of the specifications, the Archetype Definition Language parser, and RoR scaffold generator from archetype. Although some problems have emerged, most of them have been resolved. CONCLUSIONS: We have provided an agile EHR Web framework, which can build up Web systems from archetype models using RoR. The feasibility of the archetype model to provide semantic interoperability of EHRs has been demonstrated and we have verified that that it is suitable for the construction of EHR systems.

Affective computing--a mysterious tool to explore human emotions / 生物医学工程学杂志

Perception, affection and consciousness are basic psychological functions of human being. Affection is the subjective reflection of different kinds of objects. The foundation of human being's thinking is constituted by the three basic functions. Affective computing is an effective tool of revealing the affectiveness of human being in order to understand the world. Our research of affective computing focused on the relation, the generation and the influent factors among different affections. In this paper, the affective mechanism, the basic theory of affective computing, is studied, the method of acquiring and recognition of affective information is discussed, and the application of affective computing is summarized as well, in order to attract more researchers into this working area.

Revisão de literatura: Implantação de Prontuário Eletrônico do Paciente / Literature review: Implementation of Electronic Patient / Revisión de la literatura: Aplicación de la Clínica Electrónica

Estudo de revisão identificando na literatura evidencia sobre a implantação de Prontuário Eletrônico de Paciente. Utilizou-se a Biblioteca Virtual de Saúde, base de dados LILACS, PUBMED, MEDLINE, as bibliotecas eletrônicas SciELO e SBIS. Os descritores "Prontuário eletrônico", "Computação de alto desempenho", "Informática médica" e "Sistemas de informação multi-hospitalar". Foram incluídos artigos publicados entre 2005 e 2011, nos idiomas português, inglês e espanhol e disponível na íntegra. Foram identificados 68 artigos. Após a exclusão das publicações que não correspondiam os critérios de seleção obtivemos 21 artigos. Resultados e Discussão: No ano de 2010 houve maior número de publicações (24%), seguido pelos anos 2006 (19%), 2009 e 2011 (14%). Os artigos foram analisados e agrupados nas áreas: Conceitos Gerais (29%), Evolução Histórica (19%), Escolha e desenvolvimento de software (14%) e Análise de desempenho (10%). Conclusões: O sucesso ou fracasso estão intimamente ligados ao envolvimento dos usuários no planejamento e diversas fases de implantação. Chama atenção também a preocupação que o uso da informática não deve eliminar o contato com o paciente.

Study of revision to identify the available evidences in literature on the Electronic Handbook implantation of patient in the years of 2005 - 2011. It was used Virtual Library of Health, database LILACS, PUBMED, MEDLINE, SciELO and SIBS. The used describers had been "electronic Handbook", "Computation of high performance", "Computer science measured", "Systems of multi-hospital information" and "use of the scientific information in the taking of decisions in health". Results and Quarrel: In the year of 2010 it had greater publication number (24%), followed per years 2006 (19%), 2009 and 2011 (14%). The articles had been analyzed and grouped in the areas: General concepts (29%), Historical Evolution (19%), Choice and development of software (14%) and Analysis of performance (10%). Conclusions: The success or failure is closely on to the envolvement of the users in the planning and diverse phases of implantation. Flame attention also the concern that the use of computer science does not have to eliminate the contact with the patient.

Estudio de la revisión para identificar las evidencias disponibles en literatura en la implantación electrónica del manual del paciente en los años de 2005 - 2011. Era biblioteca virtual usada de la salud, de las LILAS de la base de datos, de PUBMED, de MEDLINE, de SciELO y de SIBS. Los describers usados habían sido "manual electrónico", "cómputo del alto rendimiento", "informática medida", "sistemas de la información del multi-hospital" y "uso de la información científica en tomar de decisiones en salud". Resultados y pelea: En el año de 2010 hizo el mayor número de la publicación (el 24%), seguir por los años 2006 (el 19%), 2009 y 2011 (el 14%). Los artículos habían sido analizados y agrupados en las áreas: Conceptos generales (el 29%), evolución histórica (el 19%), opción y desarrollo del software (el 14%) y análisis del funcionamiento (el 10%). Conclusiones: El éxito o la falta está de cerca encendido al envolvement de los usuarios en el planeamiento y las fases diversas de la implantación. Flamee la atención también la preocupación que el uso de la informática no tiene que eliminar el contacto con el paciente.

Computación en la nube / Cloud Computing

Durante la última década el concepto de internet ha estado presente en diversas áreas de nuestro entorno, y especialmente en Medicina. En la actualidad, el concepto más nuevo en tecnologías de información es el de cloud computing, o computación en la nube, que plantea ventajas en comparación con los esquemas tradicionales, ya que con un simple navegador podemos tener acceso a aplicaciones, plataformas e infraestructura como un servicio a través de internet, sin necesidad de un espacio en nuestros computadores personales...

During the last decade the concept of internet has been present in various areas of our environment and especially in medicine. Currently, the newest concept in information technology is “cloud” or cloud computing, posed advantages over traditional schemes, and with a simple browser can access applications, platforms and infrastructure as a service over the Internet, without a space in our personal computers...

Propuesta del Sitio Web Aprendiendo a aprender como guía para la orientación del aprendizaje / Proposing the web site Learning to learn as a guide to direct learning

Comenzar la universidad es, para los estudiantes, un verdadero desafío, ya que se enfrentan a nuevas experiencias académicas. Esto nos motivó a realizar una investigación de tipo descriptiva prospectiva con los estudiantes de primer año de Medicina de la Universidad de Ciencias Médicas Juan Guiteras Gener, de Matanzas, la cual se llevó a cabo en tres etapas. En una primera etapa se aplicó una encuesta a la muestra seleccionada, donde fueron identificadas necesidades de orientación para el aprendizaje. Los resultados se presentaron en tablas para su discusión, tomando como medida resumen los números absolutos y porcientos En una segunda, se confeccionó el Sitio Web Aprendiendo a aprender para guiar al estudiante en el proceso de aprendizaje, el cual está conformado por 10 capítulos. Y en la última, el sitio fue valorado por un grupo de expertos, los cuales lo consideraron adecuado para orientar a los estudiantes, y recomendaron su utilización para validación.

Beginning university studies is, for students, a truly challenge, because they affront new academic experiences. It motivated us carrying a prospective, descriptive, three-stage study with the first year medicine students of the Medical University Dr. Juan Guiteras Gener of Matanzas. In the first stage we applied enquire, in which the selected sample identified necessities of directing learning. The results were showed in tables for discussion, taking as a final measure absolute numbers and percents. In a second stage we prepared the 10 chapter web site Learning to learn to direct the student during the learning process. In the last stage the web site was evaluated by a group of experts, who considered it adequate to direct students, and recommended to use it for validation.

Metodología para escribir el guión de una videoclase para las carreras de la salud / Methodology to write the script of a videoclase for the races of the health

Con la introducción, en la enseñanza de las carreras de la salud, el video y la computadora, y la aplicación del Proyecto Policlínico Universitario se hizo necesaria la incorporación al trabajo en la televisión y el video de un grupo de profesores de las diferentes carreras de la salud, del ISCM-Habana, que requiere un nivel de preparación en aspectos propios del lenguaje de este importante medio para cumplir de manera satisfactoria la tarea encomendada. Este material tiene como objetivo acercar nuestro claustro al mundo del audiovisual y a la construcción de guiones, y proporciona un algoritmo de trabajo que facilita la creación de guiones para la filmación de videoclases en las carreras de la salud (AU)

With the introduction in the education of the races of the Health of the video and the computer, the application of the Policlínico Project in the Medical University, was necessary the incorporation to the work in the television took of a group of professors of UCMH, which require a level of preparation in own aspects of the language of this important one half to fulfill of satisfactory way the entrusted task. This material must as objective approach our teaching cloister to the world of the audio-visual one and the construction of scripts for the shooting of videoclases and provides one a work algorithm that facilitates the creation of scripts for the shooting of videoclases in the races of the health (AU)